Kozian D H, Kirschbaum B J
Hoechst Marion Roussel Deutschland, The Center for Applied Genomics, Martinsried, Germany.
Trends Biotechnol. 1999 Feb;17(2):73-8. doi: 10.1016/s0167-7799(98)01292-x.
The study of differences in gene-expression patterns is one of the most promising approaches for understanding mechanisms of differentiation and development. In addition, the identification of disease-related target molecules opens new avenues for rational pharmaceutical intervention. Recent technical advances and improvements are accelerating the analysis of gene-expression profiles at the transcript level. The knowledge and comprehension of currently applied methods is one of the central criteria for an efficient and successful gene-screening approach.
基因表达模式差异的研究是理解分化和发育机制最具前景的方法之一。此外，疾病相关靶分子的鉴定为合理的药物干预开辟了新途径。最近的技术进步和改进正在加速转录水平上基因表达谱的分析。了解和掌握当前应用的方法是高效成功的基因筛选方法的核心标准之一。
