Roongpisuthipong C, Panpakdee O, Boontawee A, Kulapongse S, Tanphaichitr V
Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
J Med Assoc Thai. 1999 Feb;82(2):150-9.
Fifty obese patients with a body mass index greater than 25 kg/m2 were randomized into 3 groups: control (C = 19), placebo (P = 18) and dexfenfluramine (D = 18). A behavioral modification program which included eating habits, exercise, attitudes, social relationships and six steps to lifetime weight control was taught every week. All patients strictly followed the food manual and recorded their behavior, physical activity and food intake every day through 12 weeks. Placebo and dexfenfluramine 30 mg/day were given in a double blind placebo controlled study. The results showed that all 3 groups had significant decreases in rest times and increased activity times (p < 0.05) and significant reductions of the average total daily energy, carbohydrate and fat intake (p < 0.05). They all lost weight. Mean +/- SEM cumulative weight loss was 8.3 +/- 0.7 kg in group D, 3.3 +/- 1 kg, in group P and 2.9 +/- 0.7 kg, in group C. The mean additional weight loss of 5 kg, and 5.4 kg seen with dexfenfluramine being highly significant (p < 0.001) from group P and C most likely due to increased thermogenesis. Significant (p < 0.05) and gradual reduction of biceps, triceps skinfold and per cent body fat were constantly observed only in the dexfenfluramine group. There were no significant differences among the 3 groups regarding blood pressure, heart rate, hematologic, lipids and biochemical profiles.
50名体重指数大于25kg/m²的肥胖患者被随机分为3组：对照组（C = 19）、安慰剂组（P = 18）和右芬氟拉明组（D = 18）。每周都会教授一个行为矫正项目，包括饮食习惯、运动、态度、社会关系以及终身体重控制的六个步骤。所有患者严格遵循食物手册，并在12周内每天记录他们的行为、身体活动和食物摄入量。在一项双盲安慰剂对照研究中给予安慰剂和30mg/天的右芬氟拉明。结果显示，所有3组的休息时间均显著减少，活动时间增加（p < 0.05），平均每日总能量、碳水化合物和脂肪摄入量显著降低（p < 0.05）。他们都减轻了体重。D组的平均±标准误累积体重减轻为8.3±0.7kg，P组为3.3±1kg，C组为2.9±0.7kg。右芬氟拉明组额外减轻的平均体重5kg和5.4kg与P组和C组相比具有高度显著性（p < 0.001），这很可能是由于产热增加所致。仅在右芬氟拉明组持续观察到肱二头肌、肱三头肌皮褶厚度和体脂百分比显著（p < 0.05）且逐渐降低。3组在血压、心率、血液学、血脂和生化指标方面无显著差异。
