Onodera Y, Takahashi K, Sugai Y, Yoshino M, Komatani A, Yamaguchi K, Ono S
Department of Radiology, San-yudo Hospital.
Kaku Igaku. 1999 Jan;36(1):37-44.
Whether the global liver uptake rate of 99mTc-GSA directly measured by SPECT is useful as a new index of liver function was evaluated in comparison with biochemical test results (PT%, ChE, Alb, ICG R15, KICG) and Child classification. 99mTc-GSA SPECT was performed in 157 patients with diffuse hepatic disease or hepatobiliary tumor, and two indices, namely the global liver uptake rate measured by SPECT 15 minutes after intravenous injection of 99mTc-GSA (LUS 15) and liver uptake per volume (liver uptake density) were examined. Both LUS 15 and liver uptake density were significantly correlated with biochemical test results and Child classification. In particular, close relationships between LUS 15 and ICGR15 (r = -0.720, p < 0.0001), LUS 15 and KICG (r = -0.750, p < 0.0001), and between LUS 15 and ChE (r = 0.720, p < 0.0001), indicate that LUS 15 is a useful index to evaluate liver function. Moreover, the local liver uptake rate measured by SPECT represented regional liver function and was considered a useful index to predict the function of the remnant liver after invasive treatment such as surgery.
通过单光子发射计算机断层扫描（SPECT）直接测量的99m锝-半乳糖人血清白蛋白（99mTc-GSA）的整体肝脏摄取率作为肝功能新指标是否有用，与生化检测结果（凝血酶原时间百分比、胆碱酯酶、白蛋白、吲哚菁绿15分钟滞留率、吲哚菁绿摄取常数）及Child分级进行了比较评估。对157例患有弥漫性肝病或肝胆肿瘤的患者进行了99mTc-GSA SPECT检查，并检测了两个指标，即静脉注射99mTc-GSA后15分钟通过SPECT测量的整体肝脏摄取率（LUS 15）和每体积肝脏摄取量（肝脏摄取密度）。LUS 15和肝脏摄取密度均与生化检测结果及Child分级显著相关。特别是，LUS 15与吲哚菁绿15分钟滞留率（r = -0.720，p < 0.0001）、LUS 15与吲哚菁绿摄取常数（r = -0.750，p < 0.0001）以及LUS 15与胆碱酯酶（r = 0.720，p < 0.0001）之间的密切关系表明，LUS 15是评估肝功能的有用指标。此外，通过SPECT测量的局部肝脏摄取率代表了局部肝功能，被认为是预测手术等侵入性治疗后残余肝脏功能的有用指标。
