Fujisawa H, Shinozuka A, Takenaka H
Department of Radiology, Showa University School of Medicine.
Kaku Igaku. 1997 Oct;34(10):885-99.
To evaluate regional and total liver function, 99mTc-GSA dynamic SPECT was studied in 58 patients with various liver disease and 5 normal volunteers. Using dual-head gamma camera, 60 projection data (90 seconds/rotation) were acquired to obtain SPECT imaging. Forty continuous SPECT were obtained for 60 minutes. Time activity curve (TAC) of each voxel was created. The TAC was assumed to be equally the function of C(t) = Cmax (l-e-kt). The liver uptake rate (K value) was calculated using the least squares method. The product of K value and functional volume of each voxel was defined as liver functional index and the sum of the indices was defined as total liver functional index. The total liver functional index had good correlation with various liver function test, HH15, LHL15, and the index showed significant difference between each group of Child-Pugh's liver dysfunction stage. Because of unnecessariness of setting up the ROI, this method is simple and the result is no difference among operators. Three-dimensional liver functional index map exactly shows regional liver function. So that, this method seems to be useful for predicting the residual liver function after hepatectomy.
为评估局部和整体肝功能，对58例患有各种肝脏疾病的患者及5名正常志愿者进行了99m锝-半乳糖白蛋白（99mTc-GSA）动态单光子发射计算机断层扫描（SPECT）研究。使用双头伽马相机采集60个投影数据（每旋转90秒）以获得SPECT图像。在60分钟内获取40幅连续的SPECT图像。创建每个体素的时间-活性曲线（TAC）。假定TAC等同于C(t) = Cmax (1 - e-kt)的函数。使用最小二乘法计算肝脏摄取率（K值）。每个体素的K值与功能体积的乘积被定义为肝功能指数，各指数之和被定义为整体肝功能指数。整体肝功能指数与各种肝功能检查、HH15、LHL15具有良好的相关性，并且该指数在Child-Pugh肝功能不全各阶段组之间显示出显著差异。由于无需设置感兴趣区（ROI），此方法简单且不同操作者之间结果无差异。三维肝功能指数图能准确显示局部肝功能。因此，该方法似乎对预测肝切除术后的残余肝功能有用。
