另外两例伴有4号染色体三体和双微体的急性髓系白血病中的MYC扩增。
MYC amplification in two further cases of acute myeloid leukemia with trisomy 4 and double minute chromosomes.
作者信息
O'Malley F, Rayeroux K, Cole-Sinclair M, Tong M, Campbell L J
机构信息
Victorian Cancer Cytogenetics Service, St. Vincent's Hospital, Victoria, Australia.
出版信息
Cancer Genet Cytogenet. 1999 Mar;109(2):123-5. doi: 10.1016/s0165-4608(98)00160-5.
We report two cases of trisomy 4 with double minute chromosomes (dmin): one in a woman with acute myeloid leukemia (AML), French-American-British subtype M2, the other in a man with chronic myelomonocytic leukemia. In the former case, many cells without trisomy 4 but with dmin were present, a finding not observed in previously reported cases. In both cases, fluorescence in situ hybridization studies demonstrated the double minutes to be MYC amplicons. Ten cases of AML with trisomy 4 and dmin have now been described; in the five cases investigated, the dmin have been shown to be amplified MYC gene sequences.
我们报告了两例伴有双微体染色体（dmin）的4号染色体三体病例：一例为患有急性髓系白血病（AML）、法美英协作组（FAB）M2亚型的女性，另一例为患有慢性粒单核细胞白血病的男性。在前一例中，存在许多没有4号染色体三体但有双微体的细胞，这一发现是之前报道的病例中未观察到的。在这两例中，荧光原位杂交研究均证实双微体为MYC扩增子。目前已报道了10例伴有4号染色体三体和双微体的AML病例；在已研究的5例病例中，双微体已被证明是扩增的MYC基因序列。
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