Reddy K S, Sulcova V
Corning Nichols Institute, San Juan Capistrano, CA 92690-6130, USA.
Cancer Genet Cytogenet. 1997 Jun;95(2):206-9. doi: 10.1016/s0165-4608(96)00424-4.
Cytogenetic analysis of the bone marrow from a woman with preleukemia showed an aberrant clone with trisomy 4, double minutes, and a translocation t(8;9)(q21;q34). Fluorescence in situ hybridization (FISH) demonstrated that the double minutes were c-myc amplifications. A review of six cases in the literature and the present case with trisomy 4 and double minutes showed a preponderance of females and that the patients were mostly elderly. The acute myelogenous leukemia (AML) in these patients was either FAB subtype M2 or M4. In two out of seven cases, the double minutes were c-myc amplicons. The patients responded to treatment and there was karyotypic normalization during remission. There was no strong evidence of exposure to genotoxic agents.
对一名患有白血病前期的女性的骨髓进行细胞遗传学分析，结果显示存在一个异常克隆，伴有4号染色体三体、双微体以及t(8;9)(q21;q34)易位。荧光原位杂交（FISH）表明双微体为c-myc扩增。对文献中的6例病例以及本例伴有4号染色体三体和双微体的病例进行回顾发现，女性占多数，且患者大多为老年人。这些患者的急性髓系白血病（AML）要么是FAB亚型M2，要么是M4。在7例病例中的2例，双微体为c-myc扩增子。患者对治疗有反应，缓解期核型正常。没有确凿证据表明接触过基因毒性剂。
