Polito P, Dal Cin P, Sciot R, Brock P, Van Eyken P, Van den Berghe H
Center of Human Genetics, University of Leuven, Belgium.
Cancer Genet Cytogenet. 1999 Mar;109(2):161-5. doi: 10.1016/s0165-4608(98)00168-x.
An embryonal rhabdomyosarcoma, presenting as a retroperitoneal mass in a 15-year-old girl, is reported. The histological and immunohistochemical picture was typical, except for the presence of focal chondroid differentiation. Interestingly, expression of the "muscle markers" desmin and alpha-sarcomeric actin was present in the latter areas. Cytogenetic analysis showed a hyperdiploid karyotype without structural chromosome changes. The pertinent literature on the subject is reviewed. Hyperdiploidy of the clonal type seems to occur frequently, but no characteristic karyotype is so far emerging.
报告了一例15岁女孩表现为腹膜后肿块的胚胎性横纹肌肉瘤。组织学和免疫组化表现典型，只是存在局灶性软骨样分化。有趣的是，在后者区域存在“肌肉标志物”结蛋白和α-肌动蛋白的表达。细胞遗传学分析显示为超二倍体核型，无染色体结构改变。对该主题的相关文献进行了综述。克隆型超二倍体似乎经常出现，但目前尚未出现特征性核型。
