Niewiadomska H, Jeziorski A, Olborski B
Medical University, Dept. of Oncology, Lodz, Poland.
J Exp Clin Cancer Res. 1998 Dec;17(4):503-10.
The classification of histological malignancy by Bloom and Richardson used in ductal invasive breast cancer seems to be not sufficient. In the same group of patients with the same clinical status as well as pathological malignancy the prognosis can be different and unpredictable. The aim of the study was to examine a consecutive series of primary ductal invasive tumours to find out: a) the expression of some biological cellular parameters as proliferating antigens Ki67 and PCNA and the products of the suppressor gene p53; b) the correlation between the levels of expression of those factors and classical prognostic factors, such as tumour diameter, status of axillary lymph nodes, status of steroids receptors, degree of histological differentiation. It seems that the estimation of proliferating antigens together with products of suppressor gene p53 might have greater prognostic value than the estimation of single factors.
用于乳腺导管浸润癌的Bloom和Richardson组织学恶性程度分类似乎并不充分。在具有相同临床状态以及病理恶性程度的同一组患者中，预后可能不同且无法预测。本研究的目的是检查一系列连续的原发性导管浸润性肿瘤，以找出：a）一些生物学细胞参数的表达，如增殖抗原Ki67和PCNA以及抑癌基因p53的产物；b）这些因素的表达水平与经典预后因素之间的相关性，如肿瘤直径、腋窝淋巴结状态、类固醇受体状态、组织学分化程度。似乎增殖抗原与抑癌基因p53产物的评估可能比单一因素的评估具有更大的预后价值。
