Lupton J R, Turner N D
Faculty of Nutrition, Texas A&M University, College Station 77843-2471, USA.
Am J Med. 1999 Jan 25;106(1A):24S-27S. doi: 10.1016/s0002-9343(98)00343-x.
Experimental studies using high-fiber supplements show that of all the fibers tested, wheat bran is the most effective in protecting against colon tumor development. The mechanisms behind this protective effect have not been elucidated completely, and the effect is most likely multifactorial. Some mechanisms, such as luminal dilution of potential carcinogens and accelerated transit through the colon, are well established. The fermentation of wheat fiber to short-chain fatty acids--especially butyric, which has been shown to inhibit tumor growth in vitro--is documented, but interpretation of the data from animal studies and clinical trials is subject to debate. Several potential mechanisms, such as effects of phytochemicals and phytates contained in wheat bran, have not yet been explored.
使用高纤维补充剂的实验研究表明，在所有测试的纤维中，麦麸在预防结肠肿瘤发展方面最为有效。这种保护作用背后的机制尚未完全阐明，而且这种作用很可能是多因素的。一些机制，如潜在致癌物的肠腔稀释和结肠转运加速，已得到充分证实。麦麸纤维发酵产生短链脂肪酸——尤其是丁酸，丁酸已被证明在体外可抑制肿瘤生长——这一点有文献记载，但对动物研究和临床试验数据的解读仍存在争议。一些潜在机制，如麦麸中所含植物化学物质和植酸盐的作用，尚未得到探索。
