Bonnaz D
Institut de Physique de la Matière Condensée, Université de Lausanne, CH-1015 Lausanne, Switzerland.
J Theor Biol. 1999 Apr 7;197(3):415-23. doi: 10.1006/jtbi.1998.0883.
The Eigen model of molecular evolution has recently been reconsidered by taking into account the existence of non-reproducing sequences. New results obtained with this model are presented here: several time-scales characterize the population dynamics and the location of the error threshold, shifted towards larger values of the probability of mutation, depends on both the size of the population and time. Thus this model can be used to analyse extinction events. The distribution of individuals in sequence space beyond the threshold is also discussed.
最近,通过考虑非复制序列的存在,人们对分子进化的特征模型进行了重新审视。本文展示了用该模型获得的新结果:几个时间尺度表征了种群动态,并且误差阈值的位置朝着更大的突变概率值移动,这取决于种群大小和时间。因此,该模型可用于分析灭绝事件。此外,还讨论了阈值之外序列空间中个体的分布情况。