Hopewell J W, Edwards D N, Wiernik G
Br J Cancer. 1976 Dec;34(6):666-70. doi: 10.1038/bjc.1976.230.
The age and sex distribution of 1223 cases of intracranial gliomata, diagnosed in the geographical area covered by the Mersey Regional Cancer Registry over the period 1961-70, are analysed. In children and adults, the intracranial gliomata predominates in males, the tumour incidence figures indicating a ratio of 3 : 2. For young adults, the tumour incidence increases with age and is approximately the same in males and females. It is not until the age group 45-49 years is reached that the tumour incidence in males is higher. The peak tumour incidence occurs at the same age in both sexes (60-64 years) and thereafter incidence declines with age. These results are compared with previously published human data, and with the findings of experimental studies in the rat. Factors including naturally occurring changes in the hormone levels are discussed, in an attempt to explain the observed age-related sex differences.
对1961年至1970年期间在默西地区癌症登记处覆盖的地理区域内诊断出的1223例颅内胶质瘤病例的年龄和性别分布进行了分析。在儿童和成人中，颅内胶质瘤在男性中占主导地位，肿瘤发病率显示男女比例为3:2。对于年轻人，肿瘤发病率随年龄增长而增加，男性和女性大致相同。直到45-49岁年龄组，男性的肿瘤发病率才更高。肿瘤发病率的峰值在男女中出现在相同年龄（60-64岁），此后发病率随年龄下降。将这些结果与先前发表的人类数据以及大鼠实验研究的结果进行了比较。讨论了包括激素水平自然变化在内的因素，试图解释观察到的与年龄相关的性别差异。
