实验性犬瘟热感染作为一种证明亚急性铅中毒潜在影响的手段。
Experimental canine distemper infection as a means of demonstrating latent effects of subacute lead intoxication.
作者信息
White D J, McLeod S
出版信息
Br J Exp Pathol. 1976 Dec;57(6):645-52.
Observations on the response of the body to experimental infection with distemper virus in dogs previously dosed subacutely with lead have demonstrated a latent effect of lead on several body systems. Effects which indicated a relationship to earlier treatment with lead included evidence for stimulation of haemoglobin synthesis, changes to red blood cells resulting in increased destruction, increased vulnerability of the parenchymatous cells of the liver to damage, reduction in the weight of the skeleton and thyroid, an increase in weight of the thymus and brain and histopathological changes in the thymus.
对先前亚急性铅中毒的犬只感染犬瘟热病毒的实验性感染的机体反应观察表明，铅对多个身体系统有潜在影响。表明与早期铅治疗有关的影响包括血红蛋白合成受刺激的证据、导致红细胞破坏增加的红细胞变化、肝脏实质细胞对损伤的易感性增加、骨骼和甲状腺重量减轻、胸腺和大脑重量增加以及胸腺的组织病理学变化。
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