系统性红斑狼疮中β趋化因子的循环水平。
Circulating levels of beta-chemokines in systemic lupus erythematosus.
作者信息
Kaneko H, Ogasawara H, Naito T, Akimoto H, Lee S, Hishikawa T, Sekigawa I, Tokano Y, Takasaki Y, Hirose S I, Hashimoto H
机构信息
Department of Rheumatology and Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan.
出版信息
J Rheumatol. 1999 Mar;26(3):568-73.
OBJECTIVE
Recent evidence suggests the role of beta-chemokines and their receptors in human immunodeficiency virus infection. We examined the serum levels of beta-chemokines in patients with systemic lupus erythematosus (SLE).
METHODS
The serum levels of beta-chemokines, macrophage inflammatory protein-1alpha (MIP-1alpha), MIP-1beta, RANTES, and monocyte chemoattractant protein-1 (MCP-1) in patients with SLE were determined by ELISA.
RESULTS
There were significant differences between the patients with SLE and healthy controls in the serum concentrations of RANTES (p < 0.001) and MCP-1 (p < 0.01), but not MIP-1alpha (p = 0.07) and MIP-1beta (p = 0.68). A decrease of RANTES and an increase of MCP-1 was observed with the progression of disease activity in the patients with SLE.
CONCLUSION
Changes in the serum levels of RANTES and MCP-1 may indicate an interaction between SLE disease activity and the production of beta-chemokines.
目的
近期证据表明β趋化因子及其受体在人类免疫缺陷病毒感染中发挥作用。我们检测了系统性红斑狼疮（SLE）患者血清中β趋化因子的水平。
方法
采用酶联免疫吸附测定法（ELISA）检测SLE患者血清中β趋化因子、巨噬细胞炎性蛋白-1α（MIP-1α）、MIP-1β、调节激活正常T细胞表达和分泌因子（RANTES）以及单核细胞趋化蛋白-1（MCP-1）的水平。
结果
SLE患者与健康对照者血清中RANTES（p < 0.001）和MCP-1（p < 0.01）的浓度存在显著差异，但MIP-1α（p = 0.07）和MIP-1β（p = 0.68）无显著差异。随着SLE患者疾病活动度的进展，观察到RANTES水平降低，MCP-1水平升高。
结论
RANTES和MCP-1血清水平的变化可能表明SLE疾病活动度与β趋化因子产生之间存在相互作用。
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