Student Scientific Section at the Department of Internal, Autoimmune, and Metabolic Diseases, Medical University of Silesia, ul. Medyków 14, 40-752 Katowice, Poland.
Rheumatol Int. 2013 Sep;33(9):2423-7. doi: 10.1007/s00296-012-2393-5. Epub 2012 Mar 30.
Chemokines promote leukocyte traffic into the site of inflammation. Serum levels of monocyte chemotactic protein 1 (MCP-1), stromal cell-derived factor-1 (SDF-1), interferon-gamma-inducible protein 10 (IP-10), and interleukin-8 (IL-8) were evaluated in 48 treated women with systemic lupus erythematosus (SLE) and mild-to-moderate disease severity. The results were compared between the whole SLE group and the control (29 women). The relationships between chemokines, their concentrations, and peripheral blood leukocyte count and between the chemokines and individual leukocyte populations (polymorphonuclear leukocytes-PMNs, lymphocytes-Ls, monocytes-Ms, eosinophils) counts were determined. The relationships between the analyzed chemokines were also determined in the control. SLE subjects had significantly higher MCP-1, SDF-1, IP-10, and lower IL-8 concentrations compared to the control. Moderate, positive correlations between MCP-1/SDF-1, SDF-1/IP-10 and a negative correlation between MCP-1/IL8 were observed in the patient group. Moderate, negative correlations were found between SDF-1/total leukocyte count, SDF-1/absolute number of PMNs as well as between IP-10/total leukocyte count, IP-10/absolute PMNs, Ls, and Ms counts in peripheral blood of SLE group. We suggest that the obtained results and correlations observed between the examined parameters might be used to monitor SLE course and progression. However, further randomized clinical studies should be carried out on in untreated and treated patients with SLE.
趋化因子促进白细胞向炎症部位迁移。评估了 48 例患有系统性红斑狼疮(SLE)且病情处于轻度至中度的女性患者的血清单核细胞趋化蛋白 1(MCP-1)、基质细胞衍生因子-1(SDF-1)、干扰素-γ诱导蛋白 10(IP-10)和白细胞介素 8(IL-8)水平。将这些结果与整个 SLE 组和对照组(29 名女性)进行了比较。确定了趋化因子、它们的浓度与外周血白细胞计数之间的关系,以及趋化因子与单个白细胞群体(多形核白细胞-PMN、淋巴细胞-Ls、单核细胞-Ms、嗜酸性粒细胞)计数之间的关系。还在对照组中确定了分析的趋化因子之间的关系。与对照组相比,SLE 患者的 MCP-1、SDF-1、IP-10 浓度显著升高,而 IL-8 浓度显著降低。在患者组中观察到 MCP-1/SDF-1、SDF-1/IP-10 之间存在中度正相关,以及 MCP-1/IL8 之间存在负相关。在 SLE 组的外周血中,发现 SDF-1/总白细胞计数、SDF-1/绝对 PMN 数以及 SDF-1/绝对 PMN、Ls 和 Ms 数之间存在中度负相关,SDF-1/总白细胞计数、SDF-1/绝对 PMN 数以及 IP-10/总白细胞计数、IP-10/绝对 PMN、Ls 和 Ms 计数之间存在中度负相关。我们认为,获得的结果和观察到的这些参数之间的相关性可能用于监测 SLE 的病程和进展。然而,应该在未经治疗和治疗的 SLE 患者中进行进一步的随机临床试验。