van Stuijvenberg M, Jansen N E, Steyerberg E W, Derksen-Lubsen G, Moll H A
Department of Paediatrics, Sophia Children's Hospital, Rotterdam, The Netherlands.
Acta Paediatr. 1999 Jan;88(1):52-5. doi: 10.1080/08035259950170600.
The aim of this study was to assess the number of fever episodes as a risk factor for febrile seizure recurrence during the first 6 months after the last previous febrile seizure. In a 6-month follow-up study of 155 children, aged 3 months to 5 y, with a first or a recurrent febrile seizure, the occurrence of fever episodes and febrile seizure recurrences was prospectively documented. Using logistic regression analysis the association between the baseline characteristics and the number of fever episodes and the outcome, a febrile seizure recurrence, was studied. In total, 260 fever episodes were registered; 29 children experienced 1 or more febrile seizure recurrence during follow-up. Two factors were associated with febrile seizure recurrence: the number of fever episodes [odds ratio (OR)= 1.8; 95% confidence interval (CI): 1.4-2.4)] and age at study entry (OR=0.6; 95% CI: 0.3-1.1). In a multivariable model, only the number of fever episodes remained significant. In conclusion, the number of fever episodes increases the risk of a febrile seizure recurrence with a factor of 1.8 per fever episode in the first 6 months after a febrile seizure.
本研究的目的是评估发热发作次数作为上次发热性惊厥后前6个月内发热性惊厥复发危险因素的情况。在一项对155名年龄在3个月至5岁之间首次或复发性发热性惊厥儿童的6个月随访研究中，前瞻性记录了发热发作和发热性惊厥复发的发生情况。使用逻辑回归分析研究基线特征、发热发作次数与结局（发热性惊厥复发）之间的关联。总共记录了260次发热发作；29名儿童在随访期间经历了1次或更多次发热性惊厥复发。有两个因素与发热性惊厥复发相关：发热发作次数[比值比（OR）=1.8；95%置信区间（CI）：1.4 - 2.4]和研究入组时的年龄（OR = 0.6；95% CI：0.3 - 1.1）。在多变量模型中，只有发热发作次数仍然具有显著性。总之，在发热性惊厥后的前6个月内，发热发作次数使发热性惊厥复发风险增加，每次发热发作的风险系数为1.8。
