• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The up-regulation of metabotropic glutamate receptor 5 (mGluR5) in Down's syndrome brains.

作者信息

Oka A, Takashima S

机构信息

Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan.

出版信息

Acta Neuropathol. 1999 Mar;97(3):275-8. doi: 10.1007/s004010050985.

DOI:10.1007/s004010050985
PMID:10090675
Abstract

We investigated the expression of metabotropic glutamate receptor 5 (mGluR5), a subtype of group I mGluRs, in the cerebral cortex of cases with Down's syndrome (DS), using immunohistochemistry and immunoblotting with this receptor. The up-regulation of mGluR5 was observed in DS by immunohistochemistry, and atrophic pyramidal neurons were immunolabelled in elderly DS cases. Western blotting confirmed the increased expression in DS brains. Since group I mGluR regulates the metabolism of amyloid precursor protein (APP) and accelerates its processing into non-amyloidogenic APP, the overexpression of mGluR5 may be related to the pathological state of APP metabolism in DS.

摘要

相似文献

1
The up-regulation of metabotropic glutamate receptor 5 (mGluR5) in Down's syndrome brains.
Acta Neuropathol. 1999 Mar;97(3):275-8. doi: 10.1007/s004010050985.
2
Metabotropic glutamate receptor 5 in Down's syndrome hippocampus during development: increased expression in astrocytes.唐氏综合征海马体发育过程中的代谢型谷氨酸受体5：星形胶质细胞中表达增加
Curr Alzheimer Res. 2014;11(7):694-705. doi: 10.2174/1567205011666140812115423.
3
Up-regulation of E2F-1 in Down's syndrome brain exhibiting neuropathological features of Alzheimer-type dementia.
Brain Res. 2001 Jun 29;905(1-2):250-3. doi: 10.1016/s0006-8993(01)02535-5.
4
Presence of soluble amyloid beta-peptide precedes amyloid plaque formation in Down's syndrome.在唐氏综合征中，可溶性β淀粉样肽的出现先于淀粉样斑块的形成。
Nat Med. 1996 Jan;2(1):93-5. doi: 10.1038/nm0196-93.
5
Expression and cell distribution of group I and group II metabotropic glutamate receptor subtypes in taylor-type focal cortical dysplasia.I型和II型代谢型谷氨酸受体亚型在泰勒型局灶性皮质发育不良中的表达及细胞分布
Epilepsia. 2003 Jun;44(6):785-95. doi: 10.1046/j.1528-1157.2003.54802.x.
6
Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome.淀粉样前体蛋白代谢改变与唐氏综合征中的线粒体功能障碍有关。
Neuron. 2002 Feb 28;33(5):677-88. doi: 10.1016/s0896-6273(02)00604-9.
7
The developmental and aging changes of Down's syndrome cell adhesion molecule expression in normal and Down's syndrome brains.唐氏综合征细胞粘附分子在正常及唐氏综合征大脑中的发育与衰老变化
Acta Neuropathol. 2000 Dec;100(6):654-64. doi: 10.1007/s004010000230.
8
Induction of cyclo-oxygenase 2 in brains of patients with Down's syndrome and dementia of Alzheimer type: specific localization in affected neurones and axons.唐氏综合征和阿尔茨海默型痴呆患者大脑中环氧合酶2的诱导：在受影响神经元和轴突中的特异性定位
Neuroreport. 1997 Mar 24;8(5):1161-4. doi: 10.1097/00001756-199703240-00020.
9
Cellular localization of metabotropic glutamate receptors in cortical tubers and subependymal giant cell tumors of tuberous sclerosis complex.代谢型谷氨酸受体在结节性硬化症复合体的皮质结节和室管膜下巨细胞肿瘤中的细胞定位
Neuroscience. 2008 Sep 22;156(1):203-15. doi: 10.1016/j.neuroscience.2008.06.073. Epub 2008 Jul 25.
10
Life-long overexpression of S100beta in Down's syndrome: implications for Alzheimer pathogenesis.唐氏综合征中S100β的终身过度表达：对阿尔茨海默病发病机制的影响。
Neurobiol Aging. 1998 Sep-Oct;19(5):401-5. doi: 10.1016/s0197-4580(98)00074-8.

引用本文的文献

1
Current insights and prospects for the pathogenesis and treatment of clinical manifestations associated with Down syndrome through neurotransmitter, inflammatory, and oxidative stress pathways.通过神经递质、炎症和氧化应激途径对唐氏综合征相关临床表现的发病机制及治疗的当前见解与展望
Front Pharmacol. 2025 Apr 28;16:1592277. doi: 10.3389/fphar.2025.1592277. eCollection 2025.
2
A Dive Into Cerebellar Dysfunction, Motor Deficits and GABAergic Signaling in Down Syndrome.深入探讨唐氏综合征中的小脑功能障碍、运动缺陷和γ-氨基丁酸能信号传导
Cureus. 2025 Feb 25;17(2):e79623. doi: 10.7759/cureus.79623. eCollection 2025 Feb.
3
Neurodevelopmental Abnormalities in Down Syndrome: Assessing Structural and Functional Deficits.
唐氏综合征中的神经发育异常：评估结构和功能缺陷
Cureus. 2024 Dec 21;16(12):e76156. doi: 10.7759/cureus.76156. eCollection 2024 Dec.
4
Basal forebrain cholinergic neurons are vulnerable in a mouse model of Down syndrome and their molecular fingerprint is rescued by maternal choline supplementation.基底前脑胆碱能神经元在唐氏综合征小鼠模型中易受损，而母体胆碱补充可挽救其分子特征。
FASEB J. 2023 Jun;37(6):e22944. doi: 10.1096/fj.202202111RR.
5
Astrocytes in Down Syndrome Across the Lifespan.唐氏综合征患者一生中的星形胶质细胞
Front Cell Neurosci. 2021 Aug 18;15:702685. doi: 10.3389/fncel.2021.702685. eCollection 2021.
6
Group 1 Metabotropic Glutamate Receptors in Neurological and Psychiatric Diseases: Mechanisms and Prospective.Group 1 代谢型谷氨酸受体在神经和精神疾病中的作用机制及前景展望
Neuroscientist. 2022 Oct;28(5):453-468. doi: 10.1177/10738584211021018. Epub 2021 Jun 4.
7
Rethinking Intellectual Disability from Neuro- to Astro-Pathology.从神经病理学到天文病理学重新思考智力障碍
Int J Mol Sci. 2020 Nov 27;21(23):9039. doi: 10.3390/ijms21239039.
8
Fragile X and APP: a Decade in Review, a Vision for the Future.脆性 X 综合征与 APP：十年回顾，未来展望。
Mol Neurobiol. 2019 Jun;56(6):3904-3921. doi: 10.1007/s12035-018-1344-x. Epub 2018 Sep 17.
9
Metabotropic glutamate receptor 5 - a promising target in drug development and neuroimaging.代谢型谷氨酸受体5——药物研发和神经成像中有前景的靶点。
Eur J Nucl Med Mol Imaging. 2016 Jun;43(6):1151-70. doi: 10.1007/s00259-015-3301-5. Epub 2016 Jan 7.
10
Therapeutic potential of mGluR5 targeting in Alzheimer's disease.靶向代谢型谷氨酸受体5（mGluR5）在阿尔茨海默病中的治疗潜力
Front Neurosci. 2015 Jun 9;9:215. doi: 10.3389/fnins.2015.00215. eCollection 2015.