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乳鼠小肠蛋白质向循环系统的选择性摄取与转运。

The selective uptake and transmission of proteins to the circulation from the small intestine of the suckling rat.

作者信息

Jones R E

出版信息

Biochim Biophys Acta. 1976 Nov 18;451(1):151-60. doi: 10.1016/0304-4165(76)90267-1.

DOI:10.1016/0304-4165(76)90267-1
PMID:1009105
Abstract

The relative concentration of various immunoglobulins attain in the sera of 14-day-old rats have been compared 4 h after their oral and intraluminal administration. The circulatory concentration of these proteins attained higher values when they were administered into the isolated proximal small intestina than when they were administered into the distal small intestine. Selective uptake of proteins was shown to predominate in the proximal small intestine.

摘要

对14日龄大鼠经口和肠腔内给药4小时后血清中各种免疫球蛋白的相对浓度进行了比较。当将这些蛋白质注入离体近端小肠时,其循环浓度比注入远端小肠时更高。结果表明,近端小肠中蛋白质的选择性吸收占主导地位。

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引用本文的文献

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Binding of exogenous protein fragments to native proteins: possible explanation for the overestimation of uptake of extrinsically labelled macromolecules from the gut.外源蛋白片段与天然蛋白的结合:对肠道中外源标记大分子摄取量高估的可能解释。
Immunology. 1981 Feb;42(2):251-7.