Jones R E
Biol Neonate. 1978;34(5-6):286-94. doi: 10.1159/000241142.
The absorption of 125I-labelled bovine IgG, after oral and intraluminal administration to young rats, has been followed by gel filtration and quantitatively by TCA precipitation. After intraluminal administration of the radioactive dose into the proximal small intestine most of the absorbed dose could be accounted for in a protein-bound form and the bulk of this radioactivity corresponded to native protein. Catabolism of the standard dose was far more efficient in the ileal regions of the small intestine, only 10% of the absorbed dose was transmitted as intact protein and large degradation products. Investigations on the attachment and release of labelled proteins from different sections of the small intestine of the young rat have also been recorded.
给幼鼠经口和肠腔内给予125I标记的牛IgG后，通过凝胶过滤追踪其吸收情况，并通过三氯乙酸沉淀进行定量分析。将放射性剂量经肠腔内给予近端小肠后，大部分吸收剂量以蛋白质结合形式存在，且大部分放射性与天然蛋白质相对应。标准剂量在小肠回肠区域的分解代谢效率要高得多，只有10%的吸收剂量以完整蛋白质和大的降解产物形式传递。还记录了对幼鼠小肠不同部位标记蛋白质的附着和释放情况的研究。
