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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Duval D, Dausse J P, Dardenne M

Biochim Biophys Acta. 1976 Nov 18;451(1):82-91. doi: 10.1016/0304-4165(76)90259-2.

Separation of mouse thymocytes by centrifugation on a discontinuous bovine serum albumin gradient leads to the isolation of four subpopulations of cells. 2. The study of I13H]uridine incorporation in vitro by these subpopulation in the presence of steroid shows that one of them is corticoresistant. 3. However, the binding capacity of these subpopulations measured by incubation with [3H]dexamethasone is very similar. 4. It is therefore concluded that in mouse thymus, in contrast with lymphoma cells, corticoresistance may not be explained by a defect of cytoplasmic glucocorticoid receptors.

通过在不连续的牛血清白蛋白梯度上离心分离小鼠胸腺细胞，可分离出四个细胞亚群。2. 对这些亚群在类固醇存在下体外[I13H]尿苷掺入的研究表明，其中一个亚群对皮质激素具有抗性。3. 然而，通过与[3H]地塞米松孵育测量的这些亚群的结合能力非常相似。4. 因此得出结论，在小鼠胸腺中，与淋巴瘤细胞相反，皮质抗性可能无法用细胞质糖皮质激素受体缺陷来解释。

Duval D, Dausse J P, Dardenne M

Biochim Biophys Acta. 1976 Nov 18;451(1):82-91. doi: 10.1016/0304-4165(76)90259-2.

Separation of mouse thymocytes by centrifugation on a discontinuous bovine serum albumin gradient leads to the isolation of four subpopulations of cells. 2. The study of I13H]uridine incorporation in vitro by these subpopulation in the presence of steroid shows that one of them is corticoresistant. 3. However, the binding capacity of these subpopulations measured by incubation with [3H]dexamethasone is very similar. 4. It is therefore concluded that in mouse thymus, in contrast with lymphoma cells, corticoresistance may not be explained by a defect of cytoplasmic glucocorticoid receptors.

通过在不连续的牛血清白蛋白梯度上离心分离小鼠胸腺细胞，可分离出四个细胞亚群。2. 对这些亚群在类固醇存在下体外[I13H]尿苷掺入的研究表明，其中一个亚群对皮质激素具有抗性。3. 然而，通过与[3H]地塞米松孵育测量的这些亚群的结合能力非常相似。4. 因此得出结论，在小鼠胸腺中，与淋巴瘤细胞相反，皮质抗性可能无法用细胞质糖皮质激素受体缺陷来解释。