Chanhome L, Wongtongkam N, Khow O, Pakmanee N, Omori-Satoh T, Sitprija V
Queen Saovabha Memorial Institute, Thai Red Cross Society, Bangkok, Thailand.
J Nat Toxins. 1999 Feb;8(1):135-40.
Thai commercial antivenom raised to Bungarus fasciatus venom neutralized the lethal activity of all Thai Bungarus venoms tested in in vitro neutralization experiments. The neutralizing capacities against B. fasciatus and B. candidus venoms were almost the same, but that against B. flaviceps venom was significantly greater. The efficacy of the antivenom was confirmed in in vivo neutralization experiments also. Results of immunochemical analyses supported results of the animal experiments suggesting the presence of genus specific neutralization.
用泰国产的针对银环蛇毒液的商业抗蛇毒血清在体外中和实验中中和了所有测试的泰国银环蛇属毒液的致死活性。该抗蛇毒血清对银环蛇和白链蛇毒液的中和能力几乎相同,但对黄斑渔游蛇毒液的中和能力显著更强。抗蛇毒血清的有效性在体内中和实验中也得到了证实。免疫化学分析结果支持了动物实验结果,表明存在属特异性中和作用。