Ruggiero L, De Sanctis V
Department of Pediatrics, Card. G. Panico Hospital, Tricase, Lecce, Italy.
J Pediatr Endocrinol Metab. 1998;11 Suppl 3:773-8.
The objective of this study was to determine the prevalence of fractures in transfusion-dependent thalassaemic patients in Italy. Examination of the patients' records revealed that 193 of the 977 observed patients had sustained fractures, with prevalence of 19.7%. Many patients showed multiple and recurrent fractures. Children and adolescents sustained fractures more frequently than adults. The majority of observed patients sustained fractures because of moderate or mild trauma. Our results seem to indicate that Hb pretransfusional levels over 9 or 10 gr% and serum ferritin levels under 1,000 ng/ml cannot always prevent the risk of fracture.
本研究的目的是确定意大利依赖输血的地中海贫血患者骨折的患病率。对患者记录的检查显示，在977名观察对象中，有193人发生过骨折，患病率为19.7%。许多患者表现出多处和复发性骨折。儿童和青少年比成年人更容易发生骨折。大多数观察对象因中度或轻度创伤而发生骨折。我们的结果似乎表明，输血前血红蛋白水平超过9或10克/百分比以及血清铁蛋白水平低于1000纳克/毫升并不能总是预防骨折风险。
