Kozhokaru A F, Liberman E A, Topaly V P, Topaly E E
Biofizika. 1976 Jul-Aug;21(4):766-7.
The effects of compounds (see article), where M = -S-, -SO-, -SO2- and of some of their derivatives (18 substances) on electroconductivity of bimolecular lipid membranes (BLM) of different composition in 30 mM tris-HCl (pH 7.5) is studied. The results obtained are compared with literature data concerning fasciolocide and toxic effect of these substances. Certain correlations are found between the action on BLM and biological effects of substances. The analysis of the results allowed a conclusion that the latter are concerned with a discoupling effect of substances on oxidative phosphorylation in mitochondria of helmets and their host. BLM may be applied for evaluating the value of fasciolocide and toxic effects of the substances protonophores.
研究了M = -S-、-SO-、-SO₂-的化合物（见文章）及其某些衍生物（18种物质）对30 mM三羟甲基氨基甲烷盐酸盐（pH 7.5）中不同组成的双分子脂质膜（BLM）电导率的影响。将所得结果与有关这些物质的杀片形吸虫剂和毒性作用的文献数据进行了比较。发现物质对BLM的作用与生物效应之间存在一定的相关性。对结果的分析得出结论，后者与物质对螺蛳及其宿主线粒体中氧化磷酸化的解偶联作用有关。BLM可用于评估这些物质作为杀片形吸虫剂的价值和毒性作用。
