Mefod'ev V V, Krasnov E A, Stepanova T F, Sozonova T A
Med Parazitol (Mosk). 1996 Jul-Sep(3):42-5.
Agents and biologically active fractions derived from medical plants grown in Siberia were tested in vitro and in vivo. The extract from the aspen bark displayed the highest antiopisthorchiatic activity. This agent given at a concentration of 10(-3) caused 100% death of Opisthorchis 72 hours later. In golden hamster experiments, the efficiency of the aspen bark extract was 73.48-83.0%. Butanolic and ethylacetatic extracts were found to have the greatest antiopisthorchiatic activity. The results of chemical and chromatographic studies indicated that active fractions contained salicine and its derivatives. The aspen bark extract produces no substantial toxic effect on laboratory animals and belongs to the class "Low-toxic substances".
对源自生长于西伯利亚的药用植物的制剂及生物活性成分进行了体外和体内测试。白杨树皮提取物显示出最高的抗后睾吸虫活性。该制剂在浓度为10⁻³时，72小时后可导致后睾吸虫100%死亡。在金黄仓鼠实验中，白杨树皮提取物的有效率为73.48 - 83.0%。发现正丁醇提取物和乙酸乙酯提取物具有最大的抗后睾吸虫活性。化学和色谱研究结果表明，活性成分含有水杨苷及其衍生物。白杨树皮提取物对实验动物无明显毒性作用，属于“低毒物质”类别。
