Taguchi T, Shiraogawa M, Kishida A, Akashi M
Department of Applied Chemistry and Chemical Engineering, Faculty of Engineering, Kagoshima University, Japan.
J Biomater Sci Polym Ed. 1999;10(1):19-32. doi: 10.1163/156856299x00252.
Using the biomimetic method, we formed a hydroxyapatite (HAp) layer on/in certain types of nonionic hydrogels that contain hydroxyl groups. The hydrogels used were poly(vinyl alcohol) (PVA), poly(2-hydroxyethyl methacrylate) (PHEMA), poly(glucosyloxyethyl methacrylate) (PGEMA), and agarose. Under an optical microscope, we observed a thin, continuous HAp layer on the top surface of the PVA, PHEMA, and PGEMA gels. On the other hand, we only observed an intermittent HAp layer on the surface of the agarose gel. The swelling ratio and the bound water content of these hydrogels were measured as an essential character in HAp formation. There was some relation among the HAp formation, the swelling ratios, and the bound water content.
采用仿生方法，我们在某些含羟基的非离子水凝胶上/中形成了羟基磷灰石（HAp）层。所用的水凝胶有聚乙烯醇（PVA）、聚甲基丙烯酸2-羟乙酯（PHEMA）、聚甲基丙烯酸葡糖氧基乙酯（PGEMA）和琼脂糖。在光学显微镜下，我们观察到PVA、PHEMA和PGEMA凝胶顶表面有一层薄而连续的HAp层。另一方面，我们在琼脂糖凝胶表面仅观察到间断的HAp层。测量了这些水凝胶的溶胀率和结合水含量，将其作为HAp形成过程中的一个基本特性。HAp形成、溶胀率和结合水含量之间存在一定关系。
