猿猴肠道病毒与人类肠道病毒之间的关系。

Relationships between simian and human enteroviruses.

作者信息

P Yry T, Kinnunen L, Hovi T, Hyypi T

出版信息

J Gen Virol. 1999 Mar;80 ( Pt 3):635-638. doi: 10.1099/0022-1317-80-3-635.

PMID:10092003

Abstract

Partial sequences from two genomic regions of simian enteroviruses were analysed and their relatedness to other picornaviruses was compared. Of the 18 simian viruses included in the analysis, sequences were obtained from eleven strains for at least one genomic region. In the 5' non-coding region, SV6, SV19, SV26, SV35, SV43 and SV46 (simian viruses) and BA13 (baboon virus) clearly grouped together with human enteroviruses, whereas SV4, SV28 and SA4 (South African isolate) were more distantly related. In the 3D RNA polymerase-coding region, SV26, SV35, SV43 and SV46 could be clearly identified as enteroviruses and fell into the previously defined cluster A, which contains such human viruses as coxsackievirus A16 and enterovirus 71. However, although SV6 and BA13 were also enterovirus-like, they did not belong to any known genetic cluster of human enteroviruses. Moreover, while SV18 could be recognized as a picornavirus, it did not directly group with members of the genus Enterovirus.

摘要

对猿猴肠道病毒两个基因组区域的部分序列进行了分析，并比较了它们与其他小核糖核酸病毒的亲缘关系。在分析的18种猿猴病毒中，至少从11个毒株的一个基因组区域获得了序列。在5'非编码区，SV6、SV19、SV26、SV35、SV43和SV46（猿猴病毒）以及BA13（狒狒病毒）明显与人类肠道病毒归为一类，而SV4、SV28和SA4（南非分离株）的亲缘关系较远。在3D RNA聚合酶编码区，SV26、SV35、SV43和SV46可被明确鉴定为肠道病毒，并归入先前定义的A簇，该簇包含柯萨奇病毒A16和肠道病毒71等人类病毒。然而，尽管SV6和BA13也类似肠道病毒，但它们不属于任何已知的人类肠道病毒遗传簇。此外，虽然SV18可被识别为小核糖核酸病毒，但它并未直接与肠道病毒属的成员归为一类。