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11q23处的跳跃易位伴MLL基因重排及间质端粒序列。

Jumping translocation at 11q23 with MLL gene rearrangement and interstitial telomeric sequences.

作者信息

Cuthbert G, McCullough S, Finney R, Breese G, Bown N

机构信息

Department of Human Genetics, University of Newcastle-upon-Tyne, England.

出版信息

Genes Chromosomes Cancer. 1999 Apr;24(4):295-8. doi: 10.1002/(sici)1098-2264(199904)24:4<295::aid-gcc1>3.0.co;2-8.

DOI:10.1002/(sici)1098-2264(199904)24:4<295::aid-gcc1>3.0.co;2-8
PMID:10092126
Abstract

myeloid leukemia of acute myeloid leukemia (AML) M5a showing a jumping translocation with a breakpoint at 11q23. Fluorescence in situ hybridization (FISH) demonstrated triplication of the MLL gene and the presence of interstitial telomeric sequences, supporting the role of repetitive sequences in the mechanism of jumping translocations. Southern blot analysis of the MLL breakpoint cluster region showed the presence of an MLL gene rearrangement. Jumping translocation with MLL gene rearrangement is a previously unreported phenomenon in leukemia cytogenetics.

摘要

急性髓系白血病（AML）M5a型的髓系白血病，显示11q23处有断点的跳跃性易位。荧光原位杂交（FISH）显示MLL基因三倍体及间质端粒序列的存在，支持重复序列在跳跃性易位机制中的作用。对MLL断点簇区域的Southern印迹分析显示存在MLL基因重排。伴有MLL基因重排的跳跃性易位是白血病细胞遗传学中一种先前未报道的现象。

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