Rouas-Freiss N, Khalil-Daher I, Riteau B, Menier C, Paul P, Dausset J, Carosella E D
Service de Recherches en Hémato-Immunologie, CEA/DRM/DSV, Hôpital Saint-Louis, Centre Hayem, Institut d'Hématologie, 1 avenue Claude-Vellefaux, Paris, Cedex 10, 75475, France.
Semin Cancer Biol. 1999 Feb;9(1):3-12. doi: 10.1006/scbi.1998.0103.
HLA-G is a non-classical MHC class I molecule involved in immune tolerance. We present our results concerning the effects of HLA-G on the cellular immune response, where it impairs both NK and T cell functions. We describe the NK inhibitory properties of HLA-G ex vivo, demonstrating its role in materno-fetal tolerance, which is supported by our in vitro studies using membrane-bound HLA-G1- and HLA-G2-transfected cells and a full-length soluble HLA-G molecule. We also report how HLA-G interacts at the T cell level, here exemplified by its inhibitory effect on both T cell allogeneic proliferative and Ag-specific CTL responses.
HLA-G是一种参与免疫耐受的非经典MHC I类分子。我们展示了关于HLA-G对细胞免疫反应影响的结果，它会损害自然杀伤细胞（NK）和T细胞的功能。我们描述了HLA-G在体外的NK抑制特性，证明了其在母胎耐受中的作用，这得到了我们使用膜结合的HLA-G1和HLA-G2转染细胞以及全长可溶性HLA-G分子进行的体外研究的支持。我们还报告了HLA-G在T细胞水平上的相互作用方式，这里以其对T细胞同种异体增殖和抗原特异性细胞毒性T淋巴细胞（CTL）反应的抑制作用为例进行说明。
