Gitanjali B, Rauniar G P, Shashindran C H
Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education & Research, Pondicherry, India.
Indian J Exp Biol. 1998 Dec;36(12):1216-20.
This is a single blind crossover study designed to test the effects of hyoscine butylbromide (HBB), an anticholinergic which does not cross the blood brain barrier (BBB), on the temporal changes in heart rate during nocturnal sleep. The effects were compared with atropine sulphate which is known to cross the BBB. Ten healthy male volunteers slept in the JIPMER sleep disorders laboratory for three nights and received either saline, atropine sulphate (0.4 mg, i.v.) or HBB (10 mg, i.v.) just prior to sleep onset. All night polysomnography recording was done to monitor heart rate during the specific stages of sleep. The normal physiological fall in heart rate is blunted by both drugs during slow wave sleep whereas only HBB prevented the fall in rapid eye movement sleep. Therefore, HBB may be a better choice as pre-anaesthetic medication for patients with cardiac abnormalities since it does not alter heart rate during both slow wave sleep and rapid eye movement sleep.
这是一项单盲交叉研究，旨在测试东莨菪碱丁溴酸盐（HBB）（一种不能穿过血脑屏障（BBB）的抗胆碱能药物）对夜间睡眠期间心率随时间变化的影响。将这些影响与已知能穿过血脑屏障的硫酸阿托品进行比较。十名健康男性志愿者在JIPMER睡眠障碍实验室睡了三个晚上，并在入睡前不久接受生理盐水、硫酸阿托品（0.4毫克，静脉注射）或HBB（10毫克，静脉注射）。进行整夜多导睡眠图记录以监测睡眠特定阶段的心率。在慢波睡眠期间，两种药物都会使正常的心率生理性下降变钝，而只有HBB能防止快速眼动睡眠期间的心率下降。因此，对于有心脏异常的患者，HBB可能是更好的麻醉前用药选择，因为它在慢波睡眠和快速眼动睡眠期间都不会改变心率。
