Yamashita M, Tajima K
Ibaraki Children's Hospital, Mito, Japan.
Anaesthesia. 1988 Jul;43(7):591-3. doi: 10.1111/j.1365-2044.1988.tb06698.x.
The effectiveness of hyoscine butylbromide in the prevention of edrophonium-induced bradycardia was assessed in 50 infants and children. A mixture of edrophonium (1.0 mg/kg) and either atropine (0.01 mg/kg) or hyoscine butylbromide (0.4 mg/kg) was administered to reverse the effects of tubocurarine. An initial bradycardia followed the injection of the edrophonium-atropine mixture. In contrast there was no initial decrease in heart rate after the administration of the edrophonium-hyoscine butylbromide mixture. Hyoscine butylbromide can be used with advantage as a substitute for atropine in edrophonium reversal in infants and children.
在50名婴幼儿中评估了丁溴东莨菪碱预防依酚氯铵诱发心动过缓的有效性。将依酚氯铵（1.0毫克/千克）与阿托品（0.01毫克/千克）或丁溴东莨菪碱（0.4毫克/千克）混合给药，以逆转筒箭毒碱的作用。注射依酚氯铵 - 阿托品混合物后出现初始心动过缓。相比之下，注射依酚氯铵 - 丁溴东莨菪碱混合物后心率最初没有下降。在婴幼儿依酚氯铵逆转过程中，丁溴东莨菪碱可作为阿托品的替代药物有效使用。
