乙醇诱导左旋和右旋大鼠内侧前额叶皮质多巴胺不对称性及伏隔核多巴胺代谢的差异。

Ethanol induced differences in medial prefrontal cortex dopamine asymmetry and in nucleus accumbens dopamine metabolism in left- and right-turning rats.

作者信息

Nielsen D M, Crosley K J, Keller R W, Glick S D, Carlson J N

机构信息

Department of Pharmacology and Neuroscience, Mail Code 136, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA.

出版信息

Brain Res. 1999 Mar 27;823(1-2):207-12. doi: 10.1016/s0006-8993(99)01129-4.

DOI:10.1016/s0006-8993(99)01129-4

PMID:10095029

Abstract

Ethanol (0.5 g/kg i.p.) 15 min prior to sacrifice increased homovanillic acid (HVA) levels in the left medial prefrontal cortex (mPFC) of left-turning rats and in the right mPFC of right-turning rats. In the nucleus accumbens (NAS), ethanol decreased dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), and HVA levels in rats that exhibited low levels of locomotor activity but not in rats that exhibited high levels of locomotor activity. This laboratory has previously shown that rats exhibiting differences in turning and locomotor activity behavior display different preferences for ethanol. The present results suggest that ethanol-induced differences in mPFC and NAS DA activity may be related to individual differences in the susceptibility to abuse ethanol.

摘要

在处死前15分钟腹腔注射乙醇（0.5克/千克），可使向左转大鼠左侧内侧前额叶皮质（mPFC）和向右转大鼠右侧mPFC中的高香草酸（HVA）水平升高。在伏隔核（NAS）中，乙醇降低了运动活动水平低的大鼠的多巴胺（DA）、3,4-二羟基苯乙酸（DOPAC）和HVA水平，但对运动活动水平高的大鼠没有影响。该实验室先前已表明，在转向和运动活动行为上存在差异的大鼠对乙醇表现出不同的偏好。目前的结果表明，乙醇诱导的mPFC和NAS中DA活性的差异可能与乙醇滥用易感性的个体差异有关。