Almadori G, Cadoni G, Galli J, Ferrandina G, Scambia G, Exarchakos G, Paludetti G, Ottaviani F
Institute of Otorhinolaryngology, Catholic University of the Sacred Heart, Rome, Italy.
Int J Cancer. 1999 Apr 20;84(2):188-91. doi: 10.1002/(sici)1097-0215(19990420)84:2<188::aid-ijc16>3.0.co;2-1.
Specimens of laryngeal squamous cell carcinoma (LSCC) were examined for epidermal growth factor receptor (EGFR) content using a radioreceptor method; 140 untreated consecutive patients with primary LSCC undergoing initial surgical resection were followed up for a median of 49 months (range 2-84 months) after surgery. Cox univariate regression analysis using EGFR as a continuous variable showed that EGFR levels were directly associated with the risk of lymph node metastasis. A significant relationship between EGFR status and cervical node metastasis was observed. The cutoff value of 20 fmol/mg protein was the best prognostic discriminator. The 5-year metastasis-free survival (MFS) was 66% for patients with EGFR- tumors compared with 15% for patients with EGFR+ tumors. By multivariate analysis, the EGFR status appeared to be a significant independent prognostic factor for MFS. Our results suggest that the assessment of EGFR status at the time of diagnosis may identify a subset of LSCC patients highly susceptible to neck node metastases thus defining therapy accordingly.
采用放射受体法检测喉鳞状细胞癌（LSCC）标本中的表皮生长因子受体（EGFR）含量；对140例未经治疗、接受初次手术切除的原发性LSCC连续患者术后进行了中位49个月（范围2 - 84个月）的随访。以EGFR作为连续变量进行Cox单因素回归分析显示，EGFR水平与淋巴结转移风险直接相关。观察到EGFR状态与颈部淋巴结转移之间存在显著关系。20 fmol/mg蛋白的临界值是最佳的预后判别指标。EGFR阴性肿瘤患者的5年无转移生存率（MFS）为66%，而EGFR阳性肿瘤患者为15%。通过多因素分析，EGFR状态似乎是MFS的一个显著独立预后因素。我们的结果表明，诊断时评估EGFR状态可能识别出一部分极易发生颈部淋巴结转移的LSCC患者，从而据此确定治疗方案。
