Bengtsson C, Bengtsson U
Clin Nephrol. 1976 Dec;6(6):518-22.
Urine concentration tests were performed as part of a population study in 1405 women in age strata between 38 and 60 years. The measurement of urine osmolality from the 13th hour of fluid deprivation overnight was adopted as a screening test. If an osmolality of 600 mOsm/kg H2O was not attained, a second test was performed and if this was abnormal a pitressin tannate test was carried out (54 women). Among women with a low urine concentration after pitressin tannate (less than 700 mOsm/kg H20) all but one suffered from chronic renal disease. The urine concentration capacity decreased with age illustrating the inadequacy of using the same "normal" limits at different ages. The outcome of the study raises the question of whether one simple fluid deprivation test discriminates tubular damage sufficiently satisfactorily to justify its application to the screening of large groups of people.
作为一项针对1405名年龄在38至60岁之间女性的人群研究的一部分，进行了尿液浓缩试验。采用过夜禁水13小时后测定尿渗透压作为筛查试验。如果未达到600 mOsm/kg H₂O的渗透压，则进行第二次试验，如果该试验结果异常，则进行鞣酸加压素试验（54名女性）。在鞣酸加压素试验后尿液浓缩功能低下（低于700 mOsm/kg H₂O）的女性中，除一人外均患有慢性肾病。尿液浓缩能力随年龄下降，这说明在不同年龄使用相同的“正常”界限是不恰当的。该研究结果提出了一个问题，即一项简单的禁水试验是否足以令人满意地区分肾小管损伤，从而证明其适用于对大量人群进行筛查。
