清醒且行为活跃的猴子大脑皮层功能区的光学成像
Optical imaging of functional domains in the cortex of the awake and behaving monkey.
作者信息
Vnek N, Ramsden B M, Hung C P, Goldman-Rakic P S, Roe A W
机构信息
Section of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.
出版信息
Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):4057-60. doi: 10.1073/pnas.96.7.4057.
Abstract
As demonstrated by anatomical and physiological studies, the cerebral cortex consists of groups of cortical modules, each comprising populations of neurons with similar functional properties. This functional modularity exists in both sensory and association neocortices. However, the role of such cortical modules in perceptual and cognitive behavior is unknown. To aid in the examination of this issue we have applied the high spatial resolution optical imaging methodology to the study of awake, behaving animals. In this paper, we report the optical imaging of orientation domains and blob structures, approximately 100-200 micrometer in size, in visual cortex of the awake and behaving monkey. By overcoming the spatial limitations of other existing imaging methods, optical imaging will permit the study of a wide variety of cortical functions at the columnar level, including motor and cognitive functions traditionally studied with positron-emission tomography or functional MRI techniques.
摘要
解剖学和生理学研究表明，大脑皮层由一组组皮质模块组成，每个模块都包含具有相似功能特性的神经元群体。这种功能模块化存在于感觉新皮层和联合新皮层中。然而，这种皮质模块在感知和认知行为中的作用尚不清楚。为了有助于研究这个问题，我们将高空间分辨率光学成像方法应用于对清醒、行为活动的动物的研究。在本文中，我们报告了在清醒、行为活动的猴子的视觉皮层中对大小约为100 - 200微米的取向域和斑点结构的光学成像。通过克服其他现有成像方法的空间限制，光学成像将允许在柱状水平上研究各种各样的皮质功能，包括传统上用正电子发射断层扫描或功能磁共振成像技术研究的运动和认知功能。
相似文献
1
Optical imaging of functional domains in the cortex of the awake and behaving monkey.清醒且行为活跃的猴子大脑皮层功能区的光学成像
Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):4057-60. doi: 10.1073/pnas.96.7.4057.
2
Long-term optical imaging and spectroscopy reveal mechanisms underlying the intrinsic signal and stability of cortical maps in V1 of behaving monkeys.长期光学成像和光谱学揭示了行为猕猴初级视皮层中内在信号和皮层图谱稳定性的潜在机制。
J Neurosci. 2000 Nov 1;20(21):8111-21. doi: 10.1523/JNEUROSCI.20-21-08111.2000.
3
Simultaneous mapping of binocular and monocular receptive fields in awake monkeys for calibrating eye alignment in a dichoptical setup.在清醒猴子中同时绘制双眼和单眼感受野，用于在双眼分视设置中校准眼位对准。
J Neurosci Methods. 2003 Jun 15;126(1):41-56. doi: 10.1016/s0165-0270(03)00067-0.
4
Dichoptic visual masking reveals that early binocular neurons exhibit weak interocular suppression: implications for binocular vision and visual awareness.双眼分视视觉掩蔽表明，早期双眼神经元表现出较弱的眼间抑制：对双眼视觉和视觉意识的影响。
J Cogn Neurosci. 2004 Jul-Aug;16(6):1049-59. doi: 10.1162/0898929041502788.
5
Air-driven eye shutter system for vision experiments using awake behaving animals.用于使用清醒行为动物进行视觉实验的气动眼部快门系统。
J Neurosci Methods. 2006 May 15;153(1):130-4. doi: 10.1016/j.jneumeth.2005.10.013. Epub 2005 Nov 28.
6
Intrinsic signal recording from a monkey whose behavior was maintained by a schedule of reinforcement.从一只行为由强化程序维持的猴子身上进行的内在信号记录。
Neurosci Res. 2004 Sep;50(1):45-53. doi: 10.1016/j.neures.2004.05.008.
7
The temporal-spatial dynamics of feature maps during monocular deprivation revealed by chronic imaging and self-organization model simulation.通过长期成像和自组织模型模拟揭示的单眼剥夺期间特征图的时空动态。
Neuroscience. 2016 Dec 17;339:571-586. doi: 10.1016/j.neuroscience.2016.10.014. Epub 2016 Oct 13.
8
Visual processing in the ketamine-anesthetized monkey. Optokinetic and blood oxygenation level-dependent responses.氯胺酮麻醉猴的视觉处理。视动反应和血氧水平依赖反应。
Exp Brain Res. 2002 Apr;143(3):359-72. doi: 10.1007/s00221-001-0998-0. Epub 2002 Jan 31.
9
Differential processing of binocular and monocular gloss cues in human visual cortex.人类视觉皮层中双眼和单眼光泽线索的差异处理
J Neurophysiol. 2016 Jun 1;115(6):2779-90. doi: 10.1152/jn.00829.2015. Epub 2016 Feb 24.
10
High-resolution optical imaging of functional brain architecture in the awake monkey.清醒猴子大脑功能结构的高分辨率光学成像
Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11559-63. doi: 10.1073/pnas.88.24.11559.
引用本文的文献
1
A Neural Implant Design Toolbox for Nonhuman Primates.用于非人类灵长类动物的神经植入设计工具包。
J Vis Exp. 2024 Feb 9(204). doi: 10.3791/66167.
2
Mesoscopic calcium imaging in a head-unrestrained male non-human primate using a lensless microscope.使用无透镜显微镜对头不固定的雄性非人类灵长类动物进行介观钙成像。
Nat Commun. 2024 Feb 10;15(1):1271. doi: 10.1038/s41467-024-45417-6.
3
Photoacoustic imaging of squirrel monkey cortical responses induced by peripheral mechanical stimulation.外周机械刺激诱导松鼠猴皮质反应的光声成像。
J Biophotonics. 2024 Mar;17(3):e202300347. doi: 10.1002/jbio.202300347. Epub 2024 Jan 3.
4
ON and OFF Signaling Pathways in the Retina and the Visual System.视网膜与视觉系统中的开与关信号通路
Front Ophthalmol (Lausanne). 2022;2. doi: 10.3389/fopht.2022.989002. Epub 2022 Aug 26.
5
Label-free photoacoustic computed tomography of mouse cortical responses to retinal photostimulation using a pair-wise correlation map.使用成对相关图对小鼠视网膜光刺激的皮质反应进行无标记光声计算机断层扫描。
Biomed Opt Express. 2022 Jan 28;13(2):1017-1025. doi: 10.1364/BOE.446990. eCollection 2022 Feb 1.
6
Photoacoustic imaging of squirrel monkey cortical and subcortical brain regions during peripheral electrical stimulation.外周电刺激期间松鼠猴大脑皮质和皮质下脑区的光声成像
Photoacoustics. 2021 Dec 17;25:100326. doi: 10.1016/j.pacs.2021.100326. eCollection 2022 Mar.
7
In Vivo Voltage-Sensitive Dye Imaging of Subcortical Brain Function.皮层下脑功能的体内电压敏感染料成像
Sci Rep. 2015 Nov 27;5:17325. doi: 10.1038/srep17325.
8
Photoacoustic detection of functional responses in the motor cortex of awake behaving monkey during forelimb movement.在清醒活动的猴子进行前肢运动期间，对运动皮层中的功能反应进行光声检测。
J Biomed Opt. 2012 Nov;17(11):110503. doi: 10.1117/1.JBO.17.11.110503.
9
Frontiers in optical imaging of cerebral blood flow and metabolism.脑血流和代谢的光学成像前沿。
J Cereb Blood Flow Metab. 2012 Jul;32(7):1259-76. doi: 10.1038/jcbfm.2011.195. Epub 2012 Jan 18.
10
Functional magnetic resonance imaging of awake monkeys: some approaches for improving imaging quality.清醒猴子的功能磁共振成像：提高成像质量的一些方法。
Magn Reson Imaging. 2012 Jan;30(1):36-47. doi: 10.1016/j.mri.2011.09.010. Epub 2011 Nov 3.
本文引用的文献
1
Response of anterior parietal cortex to different modes of same-site skin stimulation.顶叶前皮质对同一部位皮肤不同刺激模式的反应。
J Neurophysiol. 1998 Dec;80(6):3272-83. doi: 10.1152/jn.1998.80.6.3272.
2
Functional magnetic resonance imaging in macaque cortex.猕猴皮层的功能磁共振成像
Neuroreport. 1998 Jul 13;9(10):2213-8. doi: 10.1097/00001756-199807130-00012.
3
fMRI of monkey visual cortex.猴子视觉皮层的功能磁共振成像
Neuron. 1998 Jun;20(6):1051-7. doi: 10.1016/s0896-6273(00)80485-7.
4
Maps of complex motion selectivity in the superior temporal cortex of the alert macaque monkey: a double-label 2-deoxyglucose study.警觉猕猴颞上叶皮质复杂运动选择性图谱：一项双标记2-脱氧葡萄糖研究
Cereb Cortex. 1997 Dec;7(8):749-57. doi: 10.1093/cercor/7.8.749.
5
Orientation maps of subjective contours in visual cortex.视觉皮层中主观轮廓的定向图。
Science. 1996 Dec 20;274(5295):2110-5. doi: 10.1126/science.274.5295.2110.
6
Development of orientation preference maps in ferret primary visual cortex.雪貂初级视觉皮层中方向偏好图的发育
J Neurosci. 1996 Oct 15;16(20):6443-53. doi: 10.1523/JNEUROSCI.16-20-06443.1996.
7
Suprathreshold auditory cortex activation visualized by intrinsic signal optical imaging.通过内在信号光学成像可视化的阈上听觉皮层激活。
Cereb Cortex. 1996 Mar-Apr;6(2):120-30. doi: 10.1093/cercor/6.2.120.
8
Characterization of functional organization within rat barrel cortex using intrinsic signal optical imaging through a thinned skull.通过薄颅骨利用内在信号光学成像对大鼠桶状皮层内的功能组织进行表征。
Proc Natl Acad Sci U S A. 1993 Nov 1;90(21):9998-10002. doi: 10.1073/pnas.90.21.9998.
9
Coactivation of prefrontal cortex and inferior parietal cortex in working memory tasks revealed by 2DG functional mapping in the rhesus monkey.恒河猴2DG功能图谱揭示工作记忆任务中前额叶皮层与顶下小叶皮层的共同激活
J Neurosci. 1994 May;14(5 Pt 1):2775-88. doi: 10.1523/JNEUROSCI.14-05-02775.1994.
10
Multiple processing streams in occipitotemporal visual cortex.枕颞视觉皮层中的多个处理流
Nature. 1994 Sep 8;371(6493):151-4. doi: 10.1038/371151a0.
Zotero 插件