Manukhin B N, Berdysheva L V, Boĭko O V, Kichikulova T P, Nesterova L A
N. K. Kol'tsov Institute of Developmental Biology of the Russian Acad. Sci., Moscow, Russia.
Ross Fiziol Zh Im I M Sechenova. 1998 Oct;84(10):1049-60.
In isolated smooth muscles of the sea cucumber, the rat intestine, vas deferens and portal vein, and in chick embryonic amnion, contractile responses of smooth muscles to transmitters and their agonists were described with two equations: p = (Pm.A(n))/(EC50n + A(n)) [7] or p = [(Pm1.An1)/(EC50(1)n1 + An1)] + [(Pm2.An2)/(EC50(2)n2 + An2)] [8]. The findings reveal a possibility of ligand-receptor interaction according to several models: a single receptor pool with n = 1 or n not equal to 1; two receptor pools in the same effector system with n1 = n2 or n1 not equal to n2.
