Raevskiĭ K S, Bashkatova V G, Narkevich V B, Vitskova G Iu, Mikoian V D, Vanin A F
Institute of Pharmacology, Russian Acad. Med. Sci., Russia, Moscow.
Ross Fiziol Zh Im I M Sechenova. 1998 Oct;84(10):1093-9.
Seizures induced with Thiosemicarbaside, Pentylenetetrasole, N-methyl-D,L-aspartate were used as models. The NO content increased 4-5-fold in the brain cortex at the peak of seizures. The increase could be prevented by pre-treatment with N-nitro-L-arginine and the seizures were weakened. Anticonvulsant drugs reduced the seizure manifestations and partially prevented the NO generation enhancement. The latter seems to be involved in pathophysiological mechanisms underlying the seizures.
以氨基硫脲、戊四氮、N-甲基-D,L-天冬氨酸诱导的癫痫发作作为模型。癫痫发作高峰期，大脑皮层中的一氧化氮（NO）含量增加了4至5倍。这种增加可通过用N-硝基-L-精氨酸预处理来预防，并且癫痫发作会减弱。抗惊厥药物减轻了癫痫发作表现，并部分阻止了NO生成的增强。后者似乎参与了癫痫发作的病理生理机制。
