Raevskiĭ K S, Bashkatova V G, Vitskova G Iu, Narkevich V B, Mikoian V D, Vanin A F
Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
Eksp Klin Farmakol. 1998 Jan-Feb;61(1):13-6.
EPR-spectrometry was performed to study the nitrous oxide (NO) content and the intensity of lipid peroxidation (LPO) in the brain cortex of rats during convulsions induced by intracerebral injection of N-methyl-D,L-aspartate (NMDLA). It was shown that the convulsions were attended with a fourfold increase in the NO content and activation of LPO in the rat brain cortex. Disocilpin injection fully prevented the development of convulsions as well as increase in the NO level and LPO activation caused by NMDLA injection. N-nitro-L-arginine had an anticonvulsive effect and prevented increase in the NO content but did not cause any noticeable effect on LPO intensity in the brain cortex.
采用电子顺磁共振光谱法研究脑内注射N-甲基-D，L-天冬氨酸（NMDLA）诱导大鼠惊厥时大脑皮质中一氧化氮（NO）含量及脂质过氧化（LPO）强度。结果表明，惊厥发作时大鼠大脑皮质中NO含量增加了四倍，且LPO被激活。注射地索茶碱可完全预防惊厥发作，以及NMDLA注射引起的NO水平升高和LPO激活。N-硝基-L-精氨酸具有抗惊厥作用，可防止NO含量增加，但对大脑皮质中LPO强度无明显影响。
