Zborovskiĭ A B, Sivordova L E, Derevianko L I, Zborovskaia I A, Zavodovskiĭ B V
Ter Arkh. 1999;71(1):60-3.
To optimize treatment for rheumatoid arthritis (RA) and to define indications for D-penicillamine and methotrexate therapies on an individual basis by taking into account the levels of rheumatoid factor (RF) isotopes circulating in blood.
A total of 105 patients (mean age 46.39 +/- 1.35 years) with varying RA were observed. Indirect solid-phase enzyme immunoassay was used to analyze RF isotopes; the pattern of the disease and the efficiency of therapy for RA were compared with the patients' immunity.
With elevated RF IgG levels, the cardiovascular system, thyroid, mucous membranes were found to be more frequently impaired and vasculitis was diagnosed.
The use of cuprenil and methotrexate in RA substantially improves patients' immunity.
通过考虑血液中循环的类风湿因子（RF）同位素水平，优化类风湿关节炎（RA）的治疗，并在个体基础上确定青霉胺和甲氨蝶呤疗法的适应症。
观察了105例不同病情的RA患者（平均年龄46.39±1.35岁）。采用间接固相酶免疫分析法分析RF同位素；将疾病模式和RA治疗效果与患者免疫力进行比较。
随着RF IgG水平升高，发现心血管系统、甲状腺、黏膜更常受损，并诊断出血管炎。
在RA中使用青霉胺和甲氨蝶呤可显著提高患者免疫力。
