Hoang M P, Ross K F, Dawson D B, Scheuermann R H, Rogers B B
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA.
J Forensic Sci. 1999 Mar;44(2):432-7.
Investigation of sudden death in infancy is a vital function of the medical examiner's office. Surveillance of these cases may lead to recognition of new diseases or new manifestations of previously described diseases. Human herpesvirus-6 (HHV-6) is a relatively newly described virus that has been recognized as a cause of acute febrile illness in early childhood. While most cases are apparently self-limited, seven fatal cases have been reported. We present a case of a seven-month-old Latin American male with recent otitis media and vomiting who was found dead in bed. Autopsy revealed interstitial pneumonitis with an atypical polymorphous lymphocytic infiltrate in the liver, kidney, heart, spleen, lymph nodes, and bone marrow, associated with erythrophagocytosis. Polymerase chain reaction (PCR) analysis of formalin-fixed paraffin-embedded tissue was positive for HHV-6 and negative for Epstein-Barr virus (EBV) and cytomegalovirus (CMV). HHV-6 was also detected in the atypical lymphoid infiltrate by in-situ hybridization.
婴儿猝死调查是法医办公室的一项重要职能。对这些病例的监测可能会促成对新疾病或先前描述疾病的新表现形式的识别。人类疱疹病毒6型（HHV-6）是一种相对较新描述的病毒，已被确认为幼儿急性发热性疾病的病因。虽然大多数病例显然是自限性的，但已有7例死亡病例报道。我们报告一例7个月大的拉丁裔男性病例，该患儿近期患中耳炎并伴有呕吐，被发现死在床上。尸检显示间质性肺炎，肝脏、肾脏、心脏、脾脏、淋巴结和骨髓出现非典型多形性淋巴细胞浸润，并伴有噬红细胞现象。对福尔马林固定石蜡包埋组织进行的聚合酶链反应（PCR）分析显示HHV-6呈阳性，而爱泼斯坦-巴尔病毒（EBV）和巨细胞病毒（CMV）呈阴性。通过原位杂交在非典型淋巴浸润中也检测到了HHV-6。
