Chang L, Tanaka T, Umesaki N, Ogita S
Department of Obstetrics & Gynecology, Osaka City University, Medical School, Japan.
Osaka City Med J. 1998 Dec;44(2):173-80.
Apoptotic susceptibility of epithelial cells is known to be regulated by cell adhesions to basement membranes. In this study differences in anticancer drug-sensitivities of early and advanced endometrial adenocarcinomas were examined by using highly-differentiated human endometrial adenocarcinoma cell line, HHUA, whose apoptotic susceptibility was hypothesized to be modulated by extracellular matrices. The cells express high levels of laminin receptors and laminin suppressed Fas-mediated apoptosis of the cells. However laminin did not show any effect on apoptotic susceptibility to 4 anticancer drugs. These results suggest that there is little variation in drug-sensitivity associated with disruption of endometrial stromal tissue, and that pathological staging of endometrial carcinoma is not likely to have any relation to drug sensitivity.
已知上皮细胞的凋亡易感性受细胞与基底膜黏附的调节。在本研究中，通过使用高分化人子宫内膜腺癌细胞系HHUA，检测早期和晚期子宫内膜腺癌对抗癌药物敏感性的差异，该细胞系的凋亡易感性被假定受细胞外基质调节。这些细胞表达高水平的层粘连蛋白受体，层粘连蛋白抑制细胞的Fas介导的凋亡。然而，层粘连蛋白对4种抗癌药物的凋亡易感性没有任何影响。这些结果表明，与子宫内膜间质组织破坏相关的药物敏感性几乎没有差异，并且子宫内膜癌的病理分期不太可能与药物敏感性有任何关系。
