IgA肾病和过敏性紫癜患者中的抗髓过氧化物酶抗体和抗乳铁蛋白抗体

[Anti-myeloperoxidase and anti-lactoferrin antibodies in patients with IgA nephropathy and Henoch-Schönlein purpura].

作者信息

Nishiya K, Chikazawa H, Matsumori A, Chijiwa T, Tahara K, Morita T, Hosokawa T, Ito H, Hashimoto K, Fujieda M

机构信息

Second Department of Internal Medicine, Kochi Medical School, Nankoku.

出版信息

Rinsho Byori. 1999 Feb;47(2):185-7.

PMID:10097638

Abstract

Antineutrophil cytoplasmic antibodies (ANCA) for two antigens, i.e. myeloperoxidase (MPO) and lactoferrin (LF) in sera from 19 IgA nephropathy (IgAN), 3 adult Henoch-Schönlein purpura (HSP) and 8 child HSP patients were examined by enzyme-linked immunoabsorbent assay (ELISA) for immunoglobulin isotypes. All of child HSP patients showed negative ANCA. On the other hand, one IgAN patient and two adult HSP patients showed weak positivity for IgA class anti-MPO antibody. There was no patients who showed positivity for IgG and IgM class anti-MPO antibody. In anti-LF antibody, one IgAN and one adult HSP showed positivity in IgG class; 2 IgAN and 2 HSP in IgA class and 2 IgAN and one HSP in IgM class. These results indicate that adult HSP patients have higher prevalence of IgA class anti-MPO antibody and anti-LF antibody than IgAN or child HSP.

摘要

采用酶联免疫吸附测定（ELISA）法检测19例IgA肾病（IgAN）患者、3例成人过敏性紫癜（HSP）患者和8例儿童HSP患者血清中针对两种抗原即髓过氧化物酶（MPO）和乳铁蛋白（LF）的抗中性粒细胞胞浆抗体（ANCA）的免疫球蛋白亚型。所有儿童HSP患者的ANCA均为阴性。另一方面，1例IgAN患者和2例成人HSP患者的IgA类抗MPO抗体呈弱阳性。没有患者的IgG和IgM类抗MPO抗体呈阳性。在抗LF抗体方面，1例IgAN患者和1例成人HSP患者的IgG类呈阳性；2例IgAN患者和2例HSP患者的IgA类呈阳性；2例IgAN患者和1例HSP患者的IgM类呈阳性。这些结果表明，成人HSP患者中IgA类抗MPO抗体和抗LF抗体的患病率高于IgAN患者或儿童HSP患者。