Ito T, Hiramatsu K
Department of Bacteriology, School of Medicine, Juntendo University, Tokyo, Japan.
Yonsei Med J. 1998 Dec;39(6):526-33. doi: 10.3349/ymj.1998.39.6.526.
Methicillin-resistant Staphylococcus aureus (MRSA) produces specific penicillin-binding protein, PBP2', which shows remarkably low affinities to most beta-lactam antibiotics except those such as penicillin G and ampicillin. The region surrounding mecA has been called additional DNA or mec and is thought to be of extraspecies origin. From the study of mec, we found that mec is a novel mobile genetic element and designated as staphylococcal cassette chromosome mec (SCCmec). There are three types of SCCmec. In the past decades, MRSA has become resistant to many antibiotics, such as carbapenems, new quinolones, and minocycline etc. It seems to be a characteristic of MRSA to acquire multi-resistance by accumulating multiple resistance genes around the mecA gene inside SCCmec.
耐甲氧西林金黄色葡萄球菌（MRSA）产生特异性青霉素结合蛋白PBP2'，该蛋白对大多数β-内酰胺类抗生素的亲和力极低，除了青霉素G和氨苄西林等抗生素。mecA周围的区域被称为额外DNA或mec，被认为是种外起源。通过对mec的研究，我们发现mec是一种新型移动遗传元件，并将其命名为葡萄球菌盒式染色体mec（SCCmec）。SCCmec有三种类型。在过去几十年中，MRSA已对许多抗生素产生耐药性，如碳青霉烯类、新型喹诺酮类和米诺环素等。通过在SCCmec内mecA基因周围积累多个耐药基因来获得多重耐药性似乎是MRSA的一个特征。
