Kume S, Okamura K, Tanabe D, Sakaguchi T, Nagamoto N, Fukuda S
Dept. of Surgery, Kumamoto Rosai Hospital.
Gan To Kagaku Ryoho. 1999 Mar;26(4):539-42.
A patient with advanced gastric cancer was treated with combined administration of CPT-11 CDDP and 5-FU before operation. CPT-11 was given intravenously at a dose of 30 mg/m2/day on day 1 and day 8. At the same time, 5 mg/m2/day CDDP and 350 mg/m2/day 5-FU were infused for 2 weeks. The patient experienced no other adverse reaction than a mild degree of nausea. Histological examination of the resected specimen revealed complete disappearance of cancer cells both in the stomach and the regional lymphnodes.
一名晚期胃癌患者在手术前接受了CPT-11、顺铂和5-氟尿嘧啶的联合治疗。CPT-11在第1天和第8天静脉注射，剂量为30mg/m²/天。同时，顺铂5mg/m²/天和5-氟尿嘧啶350mg/m²/天持续输注2周。该患者除了有轻度恶心外，未出现其他不良反应。切除标本的组织学检查显示，胃和区域淋巴结中的癌细胞均完全消失。
