Kagawa Shunsuke, Fujiwara Toshiyoshi, Tokunaga Naoyuki, Nishizaki Masahiko, Uno Futoshi, Teraishi Fuminori, Gouchi Akira, Matsuoka Junji, Tanaka Noriaki
Dept. of Gastroenterological Surgery, Okayama University Hospital.
Gan To Kagaku Ryoho. 2006 Sep;33(9):1317-20.
The case was a 54-year-old man with type-3 gastric cancer in the cardia accompanied by multiple liver metastasis. He received combination chemotherapy consisting of CPT-11 (60 mg/body, day 1 and 8)+low-dose 5-FU and CDDP (5-FU 500 mg/body/day and CDDP 5 mg/body/day, day 1-5 and 8-12, continuous infusion) every 3 weeks. The initial 2 courses were administered on an inpatient basis,and further courses as an outpatient. After 7 courses of therapy without severe adverse events, not only primary lesion but also hepatic metastasis disappeared. He has been free from disease for 4 months, and chemotherapy was further continued with TS-1 (100 mg/body, day 1-14)+CPT-11 60 mg/body, day 1, 8), every 3 weeks. CPT-11 in combination with low-dose 5-FU+CDDP can be one of the most effective regimens for unresectable advanced gastric cancer.
该病例为一名54岁男性，患有贲门部3型胃癌并伴有多发肝转移。他接受了由CPT-11（60mg/体，第1天和第8天）+低剂量5-氟尿嘧啶和顺铂组成的联合化疗（5-氟尿嘧啶500mg/体/天和顺铂5mg/体/天，第1 - 5天和第8 - 12天，持续输注），每3周进行一次。最初的2个疗程在住院期间给药，后续疗程为门诊给药。经过7个疗程的治疗且无严重不良事件发生后，不仅原发灶而且肝转移灶均消失。他已无病生存4个月，之后继续每3周接受TS-1（100mg/体，第1 - 14天）+CPT-11 60mg/体，第1天、第8天）的化疗。CPT-11联合低剂量5-氟尿嘧啶+顺铂可能是不可切除的晚期胃癌最有效的治疗方案之一。
