Choovoravech P, Yongpanich Y, Choovoravech N
Curr Med Res Opin. 1976;4(5):330-9. doi: 10.1185/03007997609109325.
A trial was carried out in 18 asthmatic patients to assess the effectiveness of a vaccine of house dust mite extract (Dermatophagoides pteronyssinus) absorbed on tyrosine. Patients were initially given 6 graduated doses of the vaccine subcutaneously at 7-day intervals. Maintenance injections were then given at 2-week intervals, the total dose being determined by clinical response. About 60% of the treated patients showed a significantly beneficial response to immunotherapy as assessed by symptomatic improvements. Seventy-two per cent of the patients required less oral anti-asthmatic therapy and 50% of the patients had a demonstrable increase in blocking antibodies. Local reactions were not severe and occurred infrequently. None of the patients developed systemic reactions to immunotherapy. Clinical response was found to depend to some extent on the dosage of antigen administered and rise in blocking antibodies of the patient's serum.
对18名哮喘患者进行了一项试验，以评估吸附在酪氨酸上的屋尘螨提取物（粉尘螨）疫苗的有效性。患者最初每隔7天皮下注射6剂逐渐递增剂量的疫苗。然后每隔2周进行维持注射，总剂量根据临床反应确定。根据症状改善情况评估，约60%的接受治疗的患者对免疫疗法表现出显著有益反应。72%的患者所需的口服抗哮喘治疗减少，50%的患者阻断抗体有明显增加。局部反应不严重且很少发生。没有患者对免疫疗法产生全身反应。发现临床反应在一定程度上取决于给予的抗原剂量和患者血清中阻断抗体的升高。
