支气管哮喘患者使用屋尘螨疫苗进行减敏治疗。
Hyposensitisation with house dust mite vaccine in bronchial asthma.
作者信息
Gaddie J, Skinner C, Palmer K N
出版信息
Br Med J. 1976 Sep 4;2(6035):561-2. doi: 10.1136/bmj.2.6035.561.
Abstract
In a double-blind placebo-controlled trial of tyrosine-absorbed Dermatophagoides pteronyssinus vaccine no improvement was seen in 45 patients with asthma sensitive to house dust mite. In particular there was no significant improvement in symptom scores, spirometry, and skin and nasal challenge test results. Some patients in other studies have benefited from doses of vaccine much stronger than those now commercially available, but the incidence of side effects has also been high.
摘要
在一项关于酪氨酸吸收的尘螨疫苗的双盲安慰剂对照试验中，45名对屋尘螨敏感的哮喘患者未见病情改善。特别是症状评分、肺功能测定、皮肤及鼻腔激发试验结果均无显著改善。其他研究中的一些患者受益于比目前市售剂量更强的疫苗，但副作用发生率也很高。
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本文引用的文献
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IS A MITE (DERMATOPHAGOIDES SP.) THE PRODUCER OF THE HOUSE-DUST ALLERGEN?螨虫（嗜皮螨属）是屋尘过敏原的产生者吗？
Allerg Asthma (Leipz). 1964;10:329-34.
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Mite asthma. Cause and management.螨性哮喘。病因与治疗
Practitioner. 1970 Dec;205(230):779-83.
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House-dust mite asthma. Results of challenge tests on five criteria with Dermatophagoides pteronyssinus.屋尘螨性哮喘。用粉尘螨对五项标准进行激发试验的结果。
Br Med J. 1970 May 30;2(5708):501-4. doi: 10.1136/bmj.2.5708.501.
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Hyposensitization in house dust allergy asthma. A double-blind controlled study with evaluation of the effect on bronchial sensitivity to house dust.屋尘过敏哮喘的减敏治疗。一项双盲对照研究，评估对支气管对屋尘敏感性的影响。
Acta Paediatr Scand. 1971 May;60(3):264-8. doi: 10.1111/j.1651-2227.1971.tb06655.x.
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Mites and house-dust allergy.
Lancet. 1968 Jun 15;1(7555):1270-2. doi: 10.1016/s0140-6736(68)92290-3.
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Clin Allergy. 1973 Jun;3(2):177-93. doi: 10.1111/j.1365-2222.1973.tb01320.x.
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