直接识别与间接识别：MHC抗原在移植物排斥反应中的作用
Direct and indirect recognition: the role of MHC antigens in graft rejection.
作者信息
Gould D S, Auchincloss H
机构信息
Dept of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA.
出版信息
Immunol Today. 1999 Feb;20(2):77-82. doi: 10.1016/s0167-5699(98)01394-2.
Abstract
In graft rejection, T-cell stimulation by donor APCs and self-APCs (presenting peptides of donor origin) has been called 'direct' and 'indirect' recognition, respectively. Here, Dina Gould and Hugh Auchincloss consider the traditional arguments favoring direct recognition and highlight recent findings suggesting the importance of indirect responses, thereby questioning some of our basic concepts of transplantation immunology.
摘要
在移植排斥反应中，供体抗原呈递细胞（APCs）和自身抗原呈递细胞（呈递供体来源的肽段）对T细胞的刺激分别被称为“直接”识别和“间接”识别。在此，迪娜·古尔德和休·奥金克洛斯审视了支持直接识别的传统观点，并强调了表明间接反应重要性的近期研究发现，从而对我们一些移植免疫学的基本概念提出了质疑。
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