Bradley J A
Division of Immunological Science, University of Glasgow, Scotland.
Int Rev Immunol. 1996;13(3):245-55. doi: 10.3109/08830189609061751.
Allograft rejection has been attributed predominantly to alloreactive T cells which recognize intact allogeneic MHC on donor antigen presenting cells (APC). Following transplantation, T cells may also recognize donor derived MHC antigens which have been processed and presented as antigenic peptides in the context of self-MHC by recipient APC--so called indirect allorecognition. This article discusses the possible role of indirect T cell recognition in the graft rejection response with particular emphasis on recent experimental data obtained from in vivo transplant models. Although the relative contribution of indirect allorecognition to the rejection process remains unclear the available evidence suggests that the contribution of self-MHC restricted T cells to graft rejection may have been underestimated.
同种异体移植排斥反应主要归因于同种反应性T细胞，这些T细胞识别供体抗原呈递细胞（APC）上完整的同种异体MHC。移植后，T细胞也可能识别供体来源的MHC抗原，这些抗原已被受体APC在自身MHC的背景下加工并呈递为抗原肽——即所谓的间接同种异体识别。本文讨论了间接T细胞识别在移植排斥反应中的可能作用，特别强调了从体内移植模型获得的最新实验数据。尽管间接同种异体识别对排斥过程的相对贡献仍不清楚，但现有证据表明，自身MHC限制的T细胞对移植排斥反应的贡献可能被低估了。
