Dang C V, Semenza G L
Dept of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Trends Biochem Sci. 1999 Feb;24(2):68-72. doi: 10.1016/s0968-0004(98)01344-9.
Over seven decades ago, classical biochemical studies showed that tumors have altered metabolic profiles and display high rates of glucose uptake and glycolysis. Although these metabolic changes are not the fundamental defects that cause cancer, they might confer a common advantage on many different types of cancers, which allows the cells to survive and invade. Recent molecular studies have revealed that several of the multiple genetic alterations that cause tumor development directly affect glycolysis, the cellular response to hypoxia and the ability of tumor cells to recruit new blood vessels.
七十多年前，经典的生化研究表明，肿瘤具有改变的代谢谱，表现出高葡萄糖摄取率和糖酵解率。尽管这些代谢变化并非导致癌症的根本缺陷，但它们可能赋予许多不同类型癌症一个共同优势，使细胞得以存活和侵袭。最近的分子研究表明，导致肿瘤发生的多种基因改变中有几种直接影响糖酵解、细胞对缺氧的反应以及肿瘤细胞招募新血管的能力。
