Reversal of P-glycoprotein mediated multidrug resistance by novel anthranilamide derivatives.
作者信息
Roe M, Folkes A, Ashworth P, Brumwell J, Chima L, Hunjan S, Pretswell I, Dangerfield W, Ryder H, Charlton P
机构信息
Xenova Ltd., Slough, England.
出版信息
Bioorg Med Chem Lett. 1999 Feb 22;9(4):595-600. doi: 10.1016/s0960-894x(99)00030-x.
Abstract
We have synthesised and evaluated a series of anthranilamide based modulators of P-glycoprotein. These studies have identified XR9576(2), a potent inhibitor of P-glycoprotein in vitro and in vivo. The general synthesis and the SAR of these compounds are described.
摘要
Zotero 插件