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Reversal of P-glycoprotein mediated multidrug resistance by novel anthranilamide derivatives.

作者信息

Roe M, Folkes A, Ashworth P, Brumwell J, Chima L, Hunjan S, Pretswell I, Dangerfield W, Ryder H, Charlton P

机构信息

Xenova Ltd., Slough, England.

出版信息

Bioorg Med Chem Lett. 1999 Feb 22;9(4):595-600. doi: 10.1016/s0960-894x(99)00030-x.

DOI:10.1016/s0960-894x(99)00030-x
PMID:10098671
Abstract

We have synthesised and evaluated a series of anthranilamide based modulators of P-glycoprotein. These studies have identified XR9576(2), a potent inhibitor of P-glycoprotein in vitro and in vivo. The general synthesis and the SAR of these compounds are described.

摘要

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