卡介苗预防性治疗患者中CD2 +外周血淋巴细胞亚群与膀胱癌复发之间的关联。
The association between CD2+ peripheral blood lymphocyte subsets and the relapse of bladder cancer in prophylactically BCG-treated patients.
作者信息
Reyes E, Carballido J, Manzano L, Moltó L, Olivier C, Alvarez-Mon M
机构信息
Department of Medicine, University Hospital Principe de Asturias, University of Alcalá, Madrid, Spain.
出版信息
Br J Cancer. 1999 Mar;79(7-8):1162-7. doi: 10.1038/sj.bjc.6690185.
We investigated the potential existence of differences in the distribution of T-lymphocyte subsets and in the proliferative response of these CD2+ cells to polyclonal mitogens in patients with transitional cell bladder carcinoma (SBTCC) treated with prophylactic intracavitary instillations of bacillus Calmette-Guerin (BCG) according to their clinical response to this treatment. Before BCG treatment, different subset distribution (CD8+ and CD3+ CD56+), activation antigen expression (CD3+ HLA- DR+) and proliferative response to mitogenic signals were found in CD2+ cells from SBTCC patients prophylactically treated with BCG who remained free of disease or those who had recurrence of tumour. Otherwise, the prophylactic intracavitary BCG instillations in SBTCC patients are associated with a transitory variation of T-lymphocyte subset distribution (CD4 and CD8) and activation antigens expression (CD25).
我们根据卡介苗（BCG）预防性腔内灌注治疗对移行细胞膀胱癌（SBTCC）患者的临床反应，研究了这些患者中T淋巴细胞亚群分布以及这些CD2 +细胞对多克隆有丝分裂原增殖反应的潜在差异。在BCG治疗前，在接受BCG预防性治疗且无疾病复发或肿瘤复发的SBTCC患者的CD2 +细胞中，发现了不同的亚群分布（CD8 +和CD3 + CD56 +）、活化抗原表达（CD3 + HLA - DR +）以及对有丝分裂信号的增殖反应。此外，SBTCC患者的预防性腔内BCG灌注与T淋巴细胞亚群分布（CD4和CD8）及活化抗原表达（CD25）的短暂变化有关。
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